CECAD Microsite

Publications

2018

Lang, F., Khaghani, S., Türk, C., Wiederstein, J.L., Hölper, S., Piller, T., Nogara, L., Blaauw, B., Günther, S., Müller, S., Braun, T., Krüger, M. (2018). Single muscle fiber proteomics reveals distinct protein changes in slow and fast fibers during muscle atrophy. Accepted in JPR.

Nolte, H., MacVicar, T.D., Tellkamp, F., Krüger, M. (2018). Instant Clue: A Software Suite for Interactive Data Visualization and Analysis. Sci Rep. 8(1), 12648.

Singh, I., Contreras, A., Cordero, J., Rubio, K., Dobersch, S., Günther, S., Jeratsch, S., Mehta, A., Krüger, M., Graumann, J., Seeger, W., Dobreva, G., Braun, T., Barreto, G. (2018). MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization. Nat Genet. 50(7), 990-1001.

Rinschen, M.M., Gödel, M., Grahammer, F., Zschiedrich, S., Helmstädter, M., Kretz, O., Zarei, M., Braun, D.A., Dittrich, S., Pahmeyer, C., Schroder, P., Teetzen, C., Gee, H., Daouk, G., Pohl, M., Kuhn, E., Schermer, B., Küttner, V., Boerries, M., Busch, H., Schiffer, M., Bergmann, C., Krüger, M., Hildebrandt, F., Dengjel, J., Benzing, T., Huber, T.B. (2018). A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Cell Rep. 23(8), 2495-2508.

Wiederstein, J.L., Nolte, H., Günther, S., Piller, T., Baraldo, M., Kostin, S., Bloch, W., Schindler, N., Sandri, M., Blaauw, B., Braun, T., Hölper, S., Krüger, M. (2018). Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Reports 23(5), 1342-56.

Rabiee, A., Krüger, M., Ardenkjær-Larsen, J., Kahn, C.R., Emanuelli, B. (2018). Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action. Cell Signal. 47, 1-15.

Zakrzewicz, D., Didiasova, M., Krüger, M., Giaimo, B.D., Borggrefe, T., Mieth, M., Hocke, A.C., Zakrzewicz, A., Schaefer, L., Preissner, K.T., Wygrecka, M. (2018). Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells. Biochim Biophys Acta. 1864(5 Pt A), 1816-27.

Neumann, P., Jaé, N., Knau, A., Glaser, S.F., Fouani, Y., Rossbach, O., Krüger, M., John, D., Bindereif, A., Grote, P., Boon, R.A., Dimmeler, S. (2018). The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2. Nat Commun. 9(1), 237.

2017

Awazawa, M., Gabel, P., Tsaousidou, E., Nolte, H., Krüger, M., Schmitz, J., Ackermann, P.J., Brandt, C., Altmüller, J., Motameny, S., Wunderlich, F.T., Kornfeld, J.W., Blüher, M., Brüning, J.C. (2017). A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle. Nat Med. 23(12), 1466-73.

Fang, J., Ianni, A., Smolka, C., Vakhrusheva, O., Nolte, H., Krüger, M., Wietelmann, A., Simonet, N.G., Adrian-Segarra, J.M., Vaquero, A., Braun, T., Bober, E. (2017). Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1. Proc Natl Acad Sci. 114(40), E8352-61.

Edifizi, D., Nolte, H., Babu, V., Castells-Roca, L., Mueller, M.M., Brodesser, S., Krüger, M., Schumacher, B. (2017). Cell Rep. 20(9), 2026-43.

Ianni, A., Hoelper, S., Krueger, M., Braun, T., Bober, E. (2017). Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and Sirt1. Biochem Biophys Res Commun. 492(3), 434-40.

Gedik, N., Krüger, M., Thielmann, M., Kottenberg, E., Skyschally, A., Frey, U.H., Cario, E., Peters, J., Jakob, H., Heusch, G., Kleinbongard, P. (2017). Proteomics/phosphoproteomics of left ventricular biopsies from patients with surgical coronary revascularization and pigs with coronary occlusion/reperfusion: remote ischemic preconditioning. Sci Rep. 7(1), 7629.

Vukotic, M., Nolte, H., König, T., Saita, S., Ananjew, M., Krüger, M., Tatsuta, T., Langer, T. (2017). Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Mol Cell. 67(3), 471-83.

Rajman, M., Metge, F., Fiore, R., Khudayberdiev, S., Aksoy-Aksel, A., Bicker, S., Ruedell Reschke, C., Raoof, R., Brennan, G.P., Delanty, N., Farrell, M.A., O'Brien, D.F., Bauer, S., Norwood, B., Veno, M.T., Krüger, M., Braun, T., Kjems, J., Rosenow, F., Henshall, D.C., Dieterich, C., Schratt, G. (2017). A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses. EMBO J. 36(12), 1770-87.

Bultmann-Mellin, I., Dinger, K., Debuschewitz, C., Loewe, K.M.A., Melcher, Y., Plum, M.T.W., Appel, S., Rappl, G., Willenborg, S., Schauss, A.C., Jüngst, C., Krüger, M., Dressler, S., Nakamura, T., Wempe, F., Alejandre Alcázar, M.A., Sterner-Kock, A. (2017). Role of LTBP-4 in alveolarization, angiogenesis and fibrosis in lungs. Am J Physiol Lung Cell Mol Physiol. 313(4), L687-98.

Lang, F., Aravamudhan, S., Nolte, H., Türk, C., Hölper, S., Müller, S., Günther, S., Blaauw, B., Braun, T., Krüger, M. (2017). Dynamic changes in the mouse skeletal muscle proteome during denervation-induced atrophy. Dis Model Mech. 10(7), 881-96.

Bicker, F., Vasic, V., Horta, G., Ortega, F., Nolte, H., Kavyanifar, A., Keller, S., Stankovic, N.D., Harter, P.N., Benedito, R., Lutz, B., Bäuerle, T., Hartwig, J., Baumgart, J., Krüger, M., Radyushkin, K., Alberi, L., Berninger, B., Schmidt, M.H.H. (2017). Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun. 8, 15922.

Nathan, A., Reinhardt, P., Kruspe, D., Jörß, T., Groth, M., Nolte, H., Habenicht. A., Herrmann, J., Holschbach, V., Toth, B., Krüger, M., Wang, Z.Q., Platzer, M., Englert, C. (2017). The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis. Hum Mol Genet. 26(9), 1694-1705.

Saita, S., Nolte, H., Fiedler, K.U., Kashkar, H., Venne, A.S., Zahedi, R.P., Krüger, M., Langer, T. (2017). PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis. Nat Cell Biol. 19(4), 318-28.

Rinschen, M.M., Grahammer, F., Hoppe, A.K., Kohli, P., Hagmann, H., Kretz, O., Bertsch, S., Höhne, M., Göbel, H., Bartram, M.P., Gandhirajan, R.K., Krüger, M., Brinkkoetter, P.T., Huber, T.B., Kann, M., Wickström, S.A., Benzing, T., Schermer, B. (2017). YAP-mediated mechanotransduction determines the podocyte's response to damage. Sci Signal. 10(474), eaaf8165.

2016

Shin, J., Watanabe, S., Hoelper, S., Krüger, M., Kostin, S., Pöling, J., Kubin, T., Braun, T. (2016). BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. eLife 5, e18351.

Ali, T., Krüger, M., Bhuju, S., Jarek, M., Bartkuhn, M., Renkawitz, R. (2016). Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190. Nucleic Acids Res. 45(5), 2384-95.

Szczepanowska, K., Maiti, P., Kukat, A., Hofsetz, E., Nolte, H., Senft, K., Becker, C., Ruzzenente, B., Hornig-Do, H.T., Wibom, R., Wiesner, R.J., Krüger, M., Trifunovic, A. (2016). CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J. 35(23), 2566-83.

Islam, S., Nolte, H., Jacob, W., Ziegler, A.B., Pütz, S., Grosjean, Y., Szczepanowska, K., Trifunovic, A., Braun, T., Heumann, H., Heumann, R., Hovemann, B., Moore, D.J., Krüger, M. (2016). Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Hum Mol Genet. 25(24), 5365-82.

Wai, T., Saita, S., Nolte, H., Müller, S., König, T., Richter-Dennerlein, R., Sprenger, H.G., Madrenas, J., Mühlmeister, M., Brandt, U., Krüger, M., Langer, T. (2016). The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. 17(12), 1844-56.

Marabita, M., Baraldo, M., Solagna, F., Ceelen, J., Sartori, R., Nolte, H., Nemazanyy, I., Pyronnet, S., Krüger, M., Pende, M., Blaauw, B. (2016). S6K1 is required for increasing skeletal muscle force during Hypertrophy. Cell Reports 17(2), 501-13.

Martire, A., Bedada, F.B., Uchida, S., Pöling, J., Krüger, M., Warnecke, H., Richter, M., Kubin, T., Herold, S., Braun, T. (2016). Mesenchymal stem cells attenuate inflammatory processes in the heart and lung via inhibition of TNF signaling. Basic Research in Cardiology 111(5), 54.

Housley, M.P., Njaine, B., Ricciardi, F., Stone, O.A., Hölper, S., Krüger, M., Kostin, S., Stainier, D.Y. (2016). Cavin4b/Murcb Is Required for Skeletal Muscle Development and Function in Zebrafish. PLoS Genet. 12(6), e1006099.

Boeckel, J.N., Derlet, A., Glaser, S.F., Luczak, A., Lucas, T., Heumüller, A.W., Krüger, M., Zehendner, C.M., Kaluza, D., Doddaballapur, A., Ohtani, K., Treguer, K., Dimmeler, S. (2016). JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells. Arterioscler Thromb Vasc Biol. 36(7), 1425-33.

Rodriguez-Gil, A., Ritter, O., Hornung, J., Stekman, H., Krüger, M., Braun, T., Kremmer, E., Kracht, M., Schmitz, M.L. (2016). HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell. 27(12), 1969-80.

Gerl, M.J., Bittl, V., Kirchner, S., Sachsenheimer, T., Brunner, H.L., Lüchtenborg, C., Özbalci, C., Wiedemann, H., Wegehingel, S., Nickel, W., Haberkant, P., Schultz, C., Krüger, M., Brügger, B. (2016). Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions. PLoS One 11(4), e0153009.

Aubert, G., Martin, O.J., Horton, J.L., Lai, L., Vega, R.B., Leone, T.C., Koves, T., Gardell, S.J., Krüger, M., Hoppel, C.L., Lewandowski, E.D., Crawford, P.A., Muoio, D.M., Kelly, D.P. (2016). The Failing Heart Relies on Ketone Bodies as a Fuel. Circulation 133(8), 698-705.

Bartram, M.P., Habbig, S., Pahmeyer, C., Höhne, M., Weber, L.T., Thiele, H., Altmüller, J., Kottoor, N., Wenzel, A., Krüger, M., Schermer, B., Benzing, T., Rinschen, M.M., Beck, B.B. (2016). Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS. Hum Mol Genet. 25(6), 1152-64.

Rinschen, M.M., Bharill, P., Wu, X., Kohli, P., Reinert, M.J., Kretz, O., Martinez, I.S., Schermer, B., Höhne, M., Bartram, M.P., Aravamudhan, S., Brooks, B.R., Vilchez, D., Huber, T.B., Müller, R.U., Krüger, M., Benzing, T. (2016). The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Hum Mol Genet. 25(7), 1328-44.

Horn, S., Kirkegaard, J.S., Hoelper, S., Seymour, P.A., Rescan, C., Nielsen, J.H., Madsen, O.D., Jensen, J.N., Krüger, M., Grønborg, M., Ahnfelt-Rønne, J. (2016). A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo. Mol Endocrinol. 30(1), 133-43.